This book examines the neurobiological impact of vitamins in the pathophysiology and prevention of neurodegenerative diseases, offering an integrative perspective on nutritional modulation of brain health. It explores the antioxidant, antiāinflammatory, and neurotrophic mechanisms of vitamins, alongside their pharmacokinetics, bioavailability, and bloodābrain barrier transport. With a focus on ageāassociated deficiencies, impaired absorption, and cognitive decline, it highlights mechanistic links between micronutrient status and neuronal integrity. It also investigates synergistic interactions with cofactor minerals, polyunsaturated fatty acids, and polyphenols, as well as the influence of gut microbiota on vitamināmediated neuroprotection. Specific emphasis is placed on the therapeutic implications of vitamins in Alzheimerās disease, Parkinsonās disease, amyotrophic lateral sclerosis (ALS), Huntingtonās disease, and multiple sclerosis (MS).
Key Features: Explores the neuroprotective and cognitive benefits of essential vitamins, including A, C, E, B complex, D, and K Examines pharmacokinetics, bioavailability, and bloodābrain barrier transport mechanisms relevant to vitamin efficacy Analyzes the epidemiology of vitamin deficiency, agingārelated malabsorption, and their link to cognitive impairment Highlights nutrientānutrient and vitaminādrug interactions in neurological health and therapy Provides diseaseāspecific insights into the role of vitamins in Alzheimerās disease, Parkinsonās disease, ALS, Huntingtonās disease, and MS This book is intended for researchers and students of neuroscience and nutritional sciences.
Vitamins and Neurodegeneration - Sachchida Nand Rai
This book examines the neurobiological impact of vitamins in the pathophysiology and prevention of neurodegenerative diseases, offering an integrative perspective on nutritional modulation of brain health. It explores the antioxidant, antiāinflammatory, and neurotrophic mechanisms of vitamins, alongside their pharmacokinetics, bioavailability, and bloodābrain barrier transport. With a focus on ageāassociated deficiencies, impaired absorption, and cognitive decline, it highlights mechanistic links between micronutrient status and neuronal integrity. It also investigates synergistic interactions with cofactor minerals, polyunsaturated fatty acids, and polyphenols, as well as the influence of gut microbiota on vitamināmediated neuroprotection. Specific emphasis is placed on the therapeutic implications of vitamins in Alzheimerās disease, Parkinsonās disease, amyotrophic lateral sclerosis (ALS), Huntingtonās disease, and multiple sclerosis (MS).
Key Features: Explores the neuroprotective and cognitive benefits of essential vitamins, including A, C, E, B complex, D, and K Examines pharmacokinetics, bioavailability, and bloodābrain barrier transport mechanisms relevant to vitamin efficacy Analyzes the epidemiology of vitamin deficiency, agingārelated malabsorption, and their link to cognitive impairment Highlights nutrientānutrient and vitaminādrug interactions in neurological health and therapy Provides diseaseāspecific insights into the role of vitamins in Alzheimerās disease, Parkinsonās disease, ALS, Huntingtonās disease, and MS This book is intended for researchers and students of neuroscience and nutritional sciences.